CAS Number: 142997-31-7Molecular Weight: 702.31Salt Form: N/APurity: >96%Sequence (3-letter): Suc-Ala-Leu-Pro-Phe-AMCSequence (1-letter): Suc-ALPF-AMCStorage: -20 °C or below
Suc-ALPF-AMC is a fluorogenic substrate for peptidyl prolyl cis-trans isomerases (PPIases) including FK-506 binding proteins (FKBPs, also called macrophilins) and cyclophilins. PPIases, or rotamases, catalyze the cis-trans isomerisation of proline imidic peptide bonds to accelerate protein folding.
Activity is quantified by release of free fluorescent 7-amino-4-methylcoumarin (AMC) which excites at 360-380 nm and emits at 440-460 nm.
References:
1) Ishikawa Y, Bächinger HP. A substrate preference for the rough endoplasmic reticulum resident protein FKBP22 during collagen biosynthesis. J Biol Chem. 2014 Jun 27;289(26):18189-201. doi: 10.1074/jbc.M114.561944.
| Categories | Peptides |
|---|---|
| Filter | Enzyme Substrates |
